AQUA-FAANG

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  • Home
  • Project
    • Impact
    • Partners
    • Structure
    • Early Career Researchers
  • Results
    • Deliverables
    • Datasets
    • Protocols
    • Scientific Publications
  • News & Events
  • Stakeholders
    • Exploitation WG
    • Knowledge Exchange Platform
  • Media
    • Brochures
    • Fact Sheet
    • Newsletters
    • Press Releases
    • Videos
    • Media Kit
  • External Networks
  • Contact

work package 4

WP4 - Novel approaches to reveal disease resistance (INRAE)
The overall objectives of WP4 is to establish new ways to interrogate the genomic and phenotypic basis for disease resistance in fishes, including by developing methods to enhance our understanding of and ability to measure immune cellular phenotypes and tools to functionally validate genomic regulatory elements responsible for host-defense responses. The work proposed exploits both in vivo and in vitro salmonid model systems and functional genomic investigations carried out at the tissue and cellular levels, and will provide many new methods for understanding immune mechanisms and cellular phenotypes underpinning susceptibility to bacterial and viral infection in fish.
  • Objective 4.1.
  • Objective 4.2.
  • Objective 4.3.
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Achieve a detailed functional annotation analysis of clonal rainbow trout lines with contrasted susceptibility to bacterial and viral infection.
Describe fish immune cell subsets for the first time using scRNA-Seq.
Validate genomic regions underlying immune responses via gene editing.
Links with other WPs
WP4 is complementary to WP3, as the data will provide insights into particular immune cell subtypes that may be responsible for functional-genomic responses recorded in the ImmunoMaps. Hence, there will be an extensive crosschecking of datasets between WP3 and WP4. WP4 interacts with other WPs where immune-relevant functional annotation is performed (WP3, WP5; which provide candidate genomic regions for functional validation, subgoal 4.3). WP4 interacts with WP6, as the functional annotation data will be run through comparative analysis pipelines.
WP1 - Functional annotation assays

​WP2- Bioinformatics and data analysis

WP3 - Genomic basis of immune phenotypes

​WP4 - Novel approaches to reveal disease resistance

​WP5 - Exploiting genome functional annotation to enhance fish breeding

​WP6 - Comparative analyses

WP7 - Dissemination, exploitation and communication

​WP8 - Management and coordination

WP9 - Ethics Requirements
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The AQUA-FAANG project has received funding from the European Union’s Horizon 2020 research and innovation program under Grant Agreement No 817923. This publication reflects the views only of the author, and the European Union cannot be held responsible for any use which maybe made of the information contained therein.